The differences in AA sequences permitted improvement of quantitative assays for cTnI/T. Most cTn assays are non-competitive enzyme-connected immunosorbent assays (ELISA) according to the sandwich theory, using the substantial specificity and affinity of antibodies.31 The assay relies on a seize antibody which binds to a particular epitope of cTn,
Elucidation of the physiologically distinct subunits of troponin in 1973 drastically facilitated our comprehension of cardiac contraction. While troponins are expressed in both skeletal and cardiac muscle, there are isoforms of troponin I/T expressed selectively in the center. By exploiting cardiac-restricted epitopes inside these proteins, Probabl
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